It is finally time for you to take the next step and treat your lovely skin a little bit more. And what is better than a little booster to make your skin look fresh, young and glowing again?

So the two most popular and promising treatments to achieve that, are Mesotherapy and Microneedling. Although pretty similar, these two procedures are not the same.


I remember having so many questions before my first session and I have to admit that I was a little scared too! I did a lot of research and I talked to many different experienced practitioners before choosing the right treatment for my skin.

So based on my experience and the information I got from the experts, I wanted to share with you all the answers on the questions you may have.

01. What is mesotherapy?

02. What can Mesotherapy do to my skin? (benefits)

03. Is Mesotherapy the same as Microneedling?

04. What is Microneedling good for?

05. Can Microneedling be paired with Hyalouronic Acid?

06. Dermaroller vs Dermapen (Micropen)

07. How long does microneedling for face last?

08. How often can I do dermapen?

09. What to do after dermapen treatment?

10. What skincare products can I use after microneedling?

11. Can I do mesotherapy myself? Can I use dermapen at home?

12. Is Microneedling better than chemical peel?

13. Can beauty therapists do mesotherapy?

14. Is Microneedling painful?

15. Does Microneedling work on older skin?

16. What is the downtime for dermapen?

17. Can Microneedling make skin worse? Is it normal to breakout after dermapen?

18. What should I not do before Microneedling? How do I prepare for dermapen?

What is mesotherapy?

Mesotherapy is a Greek word from “mesos” meaning middle and therapy from Greek therapeia and it is a non-surgical technique that uses micro-injections of pharmaceutical preparations, plant extracts and powerful vitamins cocktails into the mesodermal layer of the skin that aims to rejuvenate and revitalize the skin.

What can Mesotherapy do to my skin?

Mesotherapy was first developed as a treatment to remove excess fat in areas like the stomach, thighs, buttocks, hips, legs, arms, and face. Nowadays, this technique is mostly used for skin rejuvenation.

Benefits of Mesotherapy:
  • Improves dull, tired looking skin
  • Fades wrinkles and lines
  • Tightens loose skin
  • Treats acne scarring
  • Recontours the body
  • Lightens pigmented skin
  • Treats alopecia (hair loss)

Is Mesotherapy the same as Microneedling?

While Mesotherapy and Micro needling are treatments that both involve very fine needles, they are not the same.

There are differences in terms of needle length, application, depth of penetration, speed of delivery and the skin conditions they treat

Mesotherapy is a technique that injects a mix of ingredients that go directly into the middle layer of your skin using a meso device with one needle in order to rejuvenate skin or even remove excess fat.

Micro-needling is a technique using multiple microscopic needles that penetrate your skin and makes little tiny wounds. This process activates your skin’s healing process so it produces collagen and elastin which makes it very useful for general skin rejuvenation as well as to target wrinkles, enlarged pores and acne scarring.

What is Microneedling good for?

Microneedling is a process that can be used to treat many areas of our body, such as neck, arms, low neckline and face.

Benefits of Microneedling
Benefits of Microneedling
  • Improves skin tone and texture, refines pores
  • Treats the appearance of scars
  • Helps removal of stretch marks, acne scars, wrinkles, thin lines
  • Helps removal of sunspots, melasma, pigmentation marks, dark circles
  • Collagen induction

Can Microneedling be paired with Hyalouronic Acid?

Microneedling has proven to be effective on its own. However, the results can be so optimized when paired with special products and serums such as hyaluronic acid and vitamin C. The microneedling process allows the skin to better absorb products into a deeper level.


Hyaluronic acid helps adding plumpness and hydration into our skin and also prevents visible signs of aging. When Hyaluronic acid is paired with microneedling, the repair process begins almost immediately and helps better the treatment of wrinkles and scars.

Dermaroller vs Dermapen (Micropen)

Dermaroller and Dermapen are methods of microneedling which is a collagen induction therapy. Both methods use micro needles that penetrate your skin and activate the heal and repair process of your body.

They are both proven to be effective, however Dermaroller is the older method of microneedling and it is more uncomfortable and painful than the Dermapen

Dermaroller is a tool that looks like a paint roller with thin needles that is rolled by hand across the skin, allowing the needles to puncture the epidermis, creating micro-injuries that stimulate the skin’s natural healing process.


If you are about to try this technique, you want to make sure you find a very skilled and experienced professional to ensure the best results.

Also, a few more things to consider when using a dermaroller:

– It is more difficult to target small or curved areas like under or around your nose.

– You risk bending needles when penetrating scarred skin.

– The back and forth rolling technique creates larger wounds that take longer to heal.

Dermapen is an updated electronic version of the Dermaroller.

First of all, the practitioner can adjust the depth of the needles when using on different areas of your face that require different penetration levels for best results. This means control of how aggressive you want the treatment to be, less pain, less bleeding and more even results.

Microneedling pens can easily treat those hard to reach areas such as around the eyes, nose and upper lip whereas it is more difficult to reach these areas with traditional rollers.

Dermapen can penetrate the skin from up to 100 times per second with an adjustable speed so it is a lot faster than the dermaroller.

Dermapen’s needles penetrate the skin vertically, allowing for a more consistent delivery, better results and less recovery time.


How long does microneedling for face last?

Every person’s skin is different and there is no set time frame. For most people, the results of the first treatment should last on average between four to six weeks. After a few treatments and once you have reached the maximum results, you should only need maintenance treatments about twice a year.

How often can I do dermapen?

The practitioner will advise you on the frequency of treatments depending on your skin issues, your age and your skin type.

Treatments that aim to general skin rejuvenation may be repeated every 2 to 4 weeks until maximum results are achieved. Deep treatments for scars may be repeated every 4 to 6 weeks until maximum results are achieved.

After reaching the desired skin condition, a treatment twice a year should be enough to maintain your lovely fresh skin!

What to do after dermapen treatment?

After your first treatment, the practitioner will consult you on a list of post-treatment instructions to follow. It is very important to follow these instructions in order to help your skin heal so that you can get the results you wanted from the treatment.

What to avoid the first 24 hours:

Do not expose your skin in the sun light, it can cause more sun damage that usual.

Do not wash your face until the next morning, the practitioner has applied a serum of vitamins post treatment, you want to take the most out of it!

Avoid direct contact with your hair, with blankets, with your lovely pet. These could transfer unwanted germs.

Do not put on make up, try to keep your skin clean.

Try not to touch your face, but if you do, make sure you wash your hands first.

Avoid steam when cooking and sweaty situations like workout.

A few more tips for the following days:

The practitioner will advise you on what products you should use in your skin care.

You definitely have to use sunscreen every morning for the first two weeks.

Avoid any situations and workouts where you might sweat for the first 72 hours.

What skincare products can I use after microneedling?

To ensure proper healing, do not use any Alpha Hydroxy Acids, Beta Hydroxy Acid, Retinol (Vitamin A), Vitamin C (in a low pH formula) scrubs or anything perceived as “active” skincare for at least one week post treatment.


Make sure you apply sunscreen every morning, whether you will be exposed to sun light or not.

Make sure you apply a repairing night cream every night, the practinioner will suggest a list of products.

Can I do mesotherapy myself? Can I use dermapen at home?

The best advice I can give you, is “Please, don’t!!!”

Although a variety of microneedling dermarollers and dermapens is available to purchase online, the most likely thing to happen is to cause damage to your skin instead of repairing it.

I strongly believe that these tools should only be used by professionals that are able to accurately examine each person’s skin issues and proceed to the appropriate treatment. Not all skin issues require the same treatment and the products used on every person vary depending on the age, the skin condition and the desired result.

Is Microneedling better than chemical peel?

Chemical peeling works great on superficial imperfections such as wrinkles and fine lines, while microneedling works on the deeper layer of your skin to improve more troublesome skin issues.

Both are effective and can be combined for optimum results, however microneedling is a treatment with no downtime so it is mostly preferable.

Can beauty therapists do mesotherapy?

In some countries, only doctors are allowed to do mesotherapy and micro needling treatments. I live in Greece and here beauty therapists can also do these treatments, but only those who have been trained accordingly.

You want to make a research beforehand and make sure you visit a professional experienced therapist who is trained in Mesotherapy.


Is Microneedling painful?

Although microneedling is a procedure where a bunch of tiny needles are used to penetrate your skin, you will be amazed by the minimum of pain level you will experience.

The practitioner applies a numbing cream prior treatment so it is not that painful. In some areas such as the cheeks, you will not even feel a thing!

Things are even better if you choose a dermapen treatment, since the length of the needles can be adjusted to minimum when working on thin areas.

Does Microneedling work on older skin?

Yes, it can be effective in all ages. It can improve the appearance of the skin and tightens aging skin.


What is the downtime for dermapen?

With almost no downtime, dermapen is the most favourite method of microneedling. The healing process in average is 2-3 days. However, most people are ready to get back to their normal activities after 24 hours. You will experience redness that fades away within 24-48 hours.

Can Microneedling make skin worse? Is it normal to breakout after dermapen?

It is possible to experience breakouts after a microneedling treatment. Avoid picking up your skin as this may cause permanent scarring. These will clear up on their own within a few days.

It is also possible to feel that your skin looks worse during the first few days, but rest assured this is part of the healing process and it is temporary. You should expect to start seeing the results after the first week.


What should I not do before Microneedling? How do I prepare for dermapen?

You want to make sure your skin is calm before a microneedling treatment. The professionals suggest to avoid retinoids, exfoliants, topical antibiotics or acids for a week prior to your treatment, as these can make your skin more sensitive.

In Conclusion

Mesotherapy and Microneedling are definitely a must do in your list!

Microneedling for me is a game changer and dermapen is certainly a winner. I tried it and I loved it!

Fast results with almost no downtime and hardly any pain. What else can you ask for?

Whichever method you choose, make sure you seek for a professional therapist. They have the experience to understand what the needs of your skin are.

I hope you found the information helpful and if you have any comments, please let me know!